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Gene FLT3
Variant G697R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FLT3 G697R lies within the protein kinase domain of the Flt3 protein (UniProt.org). G697R has been demonstrated to occur as a secondary resistance mutation in the context of FLT3 internal tandem duplication (FLT3-ITD) mutations (PMID: 15374944, PMID: 22875611, PMID: 17827387), but has not been biochemically characterized and therefore, its effect on Flt3 protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance Y
Category Variants Paths

FLT3 mutant FLT3 exon17 FLT3 G697R

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Transcript NM_004119.3
gDNA chr13:g.28027206C>G
cDNA c.2089G>C
Protein p.G697R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119 chr13:g.28027206C>G c.2089G>C p.G697R RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28027206C>G c.2089G>C p.G697R RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28027206C>G c.2089G>C p.G697R RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References