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Gene IDH2
Variant I319M
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions IDH2 I319M does not lie within any known functional domains of the Idh2 protein (UniPort.org). I319M confers resistance to an IDH2 inhibitor in the presence of IDH2 R140Q, but retains dimerization ability and does not lead to increased production of 2HG in culture (PMID: 29950729, PMID: 36222845), and therefore, is predicted to have no effect on Idh2 protein function.
Associated Drug Resistance Y
Category Variants Paths

IDH2 mutant IDH2 I319M

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Transcript NM_002168.4
gDNA chr15:g.90087122G>C
cDNA c.957C>G
Protein p.I319M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002168.3 chr15:g.90087122G>C c.957C>G p.I319M RefSeq GRCh38/hg38
NM_002168 chr15:g.90087122G>C c.957C>G p.I319M RefSeq GRCh38/hg38
NM_002168.4 chr15:g.90087122G>C c.957C>G p.I319M RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries