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Gene | PTEN |
Variant | G156R |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | PTEN G156R lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). G156R has been identified in sequencing studies (PMID: 11123721, PMID: 27531351), but has not been biochemically characterized and therefore, its effect on Pten protein function is unknown (PubMed, Oct 2023). |
Associated Drug Resistance | |
Category Variants Paths |
PTEN mutant PTEN G156R |
Transcript | NM_000314.8 |
gDNA | chr10:g.87933225G>A |
cDNA | c.466G>A |
Protein | p.G156R |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_000314.6 | chr10:g.87933225G>A | c.466G>A | p.G156R | RefSeq | GRCh38/hg38 |
NM_000314 | chr10:g.87933225G>A | c.466G>A | p.G156R | RefSeq | GRCh38/hg38 |
NM_000314.8 | chr10:g.87933225G>A | c.466G>A | p.G156R | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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