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Gene HRAS
Variant G12E
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions HRAS G12E does not lie within any known functional domains of the Hras protein (UniProt.org). G12E results in decreased Hras GTPase activity and loss of response to GTPase-activating proteins, and is transforming in cultured cells (PMID: 24224811, PMID: 6092966).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS G12E

HRAS mutant HRAS G12X HRAS G12E

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Transcript NM_005343.4
gDNA chr11:g.534287_534288delGCinsAG
cDNA c.35_36delGCinsAG
Protein p.G12E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005343.3 chr11:g.534287_534288delGCinsAG c.35_36delGCinsAG p.G12E RefSeq GRCh38/hg38
NM_176795 chr11:g.534287_534288delGCinsCT c.35_36delGCinsAG p.G12E RefSeq GRCh38/hg38
NM_001130442 chr11:g.534287_534288delGCinsCT c.35_36delGCinsAG p.G12E RefSeq GRCh38/hg38
NM_176795.4 chr11:g.534287_534288delGCinsAG c.35_36delGCinsAG p.G12E RefSeq GRCh38/hg38
NM_005343 chr11:g.534287_534288delGCinsCT c.35_36delGCinsAG p.G12E RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.534287_534288delGCinsAG c.35_36delGCinsAG p.G12E RefSeq GRCh38/hg38
NM_005343.4 chr11:g.534287_534288delGCinsAG c.35_36delGCinsAG p.G12E RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.534287_534288delGCinsAG c.35_36delGCinsAG p.G12E RefSeq GRCh38/hg38
NM_176795.5 chr11:g.534287_534288delGCinsAG c.35_36delGCinsAG p.G12E RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References