Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Gene | HRAS |
Variant | G12I |
Impact List | missense |
Protein Effect | loss of function - predicted |
Gene Variant Descriptions | HRAS G12I does not lie within any known functional domains of the Hras protein (UniProt.org). G12I is transforming in cultured cells (PMID: 6092966), and can be predicted to lead to a loss of Hras protein function and activation of downstream signaling based on the effects of other HRAS G12 mutations. |
Associated Drug Resistance | |
Category Variants Paths |
HRAS mutant HRAS act mut HRAS G12I HRAS mutant HRAS G12X HRAS G12I |
Transcript | NM_005343.4 |
gDNA | chr11:g.534288_534289delGGinsAT |
cDNA | c.34_35delGGinsAT |
Protein | p.G12I |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_176795.5 | chr11:g.534288_534289delGGinsAT | c.34_35delGGinsAT | p.G12I | RefSeq | GRCh38/hg38 |
NM_001130442.2 | chr11:g.534288_534289delGGinsAT | c.34_35delGGinsAT | p.G12I | RefSeq | GRCh38/hg38 |
NM_005343.4 | chr11:g.534288_534289delGGinsAT | c.34_35delGGinsAT | p.G12I | RefSeq | GRCh38/hg38 |
NM_176795 | chr11:g.534288_534289delCCinsAT | c.34_35delGGinsAT | p.G12I | RefSeq | GRCh38/hg38 |
NM_005343 | chr11:g.534288_534289delCCinsAT | c.34_35delGGinsAT | p.G12I | RefSeq | GRCh38/hg38 |
NM_005343.3 | chr11:g.534288_534289delGGinsAT | c.34_35delGGinsAT | p.G12I | RefSeq | GRCh38/hg38 |
NM_176795.4 | chr11:g.534288_534289delGGinsAT | c.34_35delGGinsAT | p.G12I | RefSeq | GRCh38/hg38 |
NM_001130442.3 | chr11:g.534288_534289delGGinsAT | c.34_35delGGinsAT | p.G12I | RefSeq | GRCh38/hg38 |
NM_001130442 | chr11:g.534288_534289delCCinsAT | c.34_35delGGinsAT | p.G12I | RefSeq | GRCh38/hg38 |
Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
HRAS G12I | loss of function - predicted | MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan) |