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Gene HRAS
Variant G12L
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions HRAS G12L does not lie within any known functional domains of the Hras protein (UniProt.org). G12L is transforming in cultured cells (PMID: 6092966), and can be predicted to lead to a loss of Hras protein function and activation of downstream signaling based on the effects of other HRAS G12 mutations.
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS G12L

HRAS mutant HRAS G12X HRAS G12L

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Transcript NM_005343.4
gDNA chr11:g.534288_534289delGGinsCT
cDNA c.34_35delGGinsCT
Protein p.G12L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_176795.4 chr11:g.534288_534289delGGinsCT c.34_35delGGinsCT p.G12L RefSeq GRCh38/hg38
NM_005343.4 chr11:g.534288_534289delGGinsCT c.34_35delGGinsCT p.G12L RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.534288_534289delGGinsCT c.34_35delGGinsCT p.G12L RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.534288_534289delGGinsCT c.34_35delGGinsCT p.G12L RefSeq GRCh38/hg38
NM_005343 chr11:g.534288_534289delCCinsAG c.34_35delGGinsCT p.G12L RefSeq GRCh38/hg38
NM_176795 chr11:g.534288_534289delCCinsAG c.34_35delGGinsCT p.G12L RefSeq GRCh38/hg38
NM_176795.5 chr11:g.534288_534289delGGinsCT c.34_35delGGinsCT p.G12L RefSeq GRCh38/hg38
NM_005343.3 chr11:g.534288_534289delGGinsCT c.34_35delGGinsCT p.G12L RefSeq GRCh38/hg38
NM_001130442 chr11:g.534288_534289delCCinsAG c.34_35delGGinsCT p.G12L RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References