Gene Variant Detail

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Gene HRAS
Variant Q61V
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions HRAS Q61V does not lie within any known functional domains of the Hras protein (UniProt.org). Q61V results in decreased Hras GTPase activity and leads to transformation of cells in culture (PMID: 3510078).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS Q61V

HRAS mutant HRAS Q61X HRAS Q61V

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Transcript NM_005343.4
gDNA chr11:g.533874_533875delCAinsGT
cDNA c.181_182delCAinsGT
Protein p.Q61V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005343 chr11:g.533874_533875delTGinsAC c.181_182delCAinsGT p.Q61V RefSeq GRCh38/hg38
NM_005343.3 chr11:g.533874_533875delCAinsGT c.181_182delCAinsGT p.Q61V RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533874_533875delCAinsGT c.181_182delCAinsGT p.Q61V RefSeq GRCh38/hg38
NM_176795.5 chr11:g.533874_533875delCAinsGT c.181_182delCAinsGT p.Q61V RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533874_533875delCAinsGT c.181_182delCAinsGT p.Q61V RefSeq GRCh38/hg38
NM_001130442 chr11:g.533874_533875delTGinsAC c.181_182delCAinsGT p.Q61V RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533874_533875delCAinsGT c.181_182delCAinsGT p.Q61V RefSeq GRCh38/hg38
NM_176795.4 chr11:g.533874_533875delCAinsGT c.181_182delCAinsGT p.Q61V RefSeq GRCh38/hg38
NM_176795 chr11:g.533874_533875delTGinsAC c.181_182delCAinsGT p.Q61V RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References