HRAS Q61T
Gene Variant Detail

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Gene HRAS
Variant Q61T
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions HRAS Q61T does not lie within any known functional domains of the Hras protein (UniProt.org). Q61T confers a loss of function to Hras protein as indicated by decreased Hras GTPase activity in an in vitro assay and transformation of cells in culture (PMID: 3510078).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS Q61T

HRAS mutant HRAS Q61X HRAS Q61T

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Transcript NM_005343.4
gDNA chr11:g.533874_533875delCAinsAC
cDNA c.181_182delCAinsAC
Protein p.Q61T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005343.3 chr11:g.533874_533875delCAinsAC c.181_182delCAinsAC p.Q61T RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533874_533875delCAinsAC c.181_182delCAinsAC p.Q61T RefSeq GRCh38/hg38
NM_005343 chr11:g.533874_533875delTGinsGT c.181_182delCAinsAC p.Q61T RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533874_533875delCAinsAC c.181_182delCAinsAC p.Q61T RefSeq GRCh38/hg38
NM_176795 chr11:g.533874_533875delTGinsGT c.181_182delCAinsAC p.Q61T RefSeq GRCh38/hg38
NM_176795.5 chr11:g.533874_533875delCAinsAC c.181_182delCAinsAC p.Q61T RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533874_533875delCAinsAC c.181_182delCAinsAC p.Q61T RefSeq GRCh38/hg38
NM_176795.4 chr11:g.533874_533875delCAinsAC c.181_182delCAinsAC p.Q61T RefSeq GRCh38/hg38
NM_001130442 chr11:g.533874_533875delTGinsGT c.181_182delCAinsAC p.Q61T RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References