HRAS Q61Y
Gene Variant Detail

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Gene HRAS
Variant Q61Y
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions HRAS Q61Y does not lie within any known functional domains of the Hras protein (UniProt.org). Q61Y is transforming in culture (PMID: 3510078) and therefore, is predicted to lead to a loss of Hras protein function and activation of downstream signaling.
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS Q61Y

HRAS mutant HRAS Q61X HRAS Q61Y

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Transcript NM_005343.4
gDNA chr11:g.533873_533875delCAGinsTAT
cDNA c.181_183delCAGinsTAT
Protein p.Q61Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001130442.2 chr11:g.533873_533875delCAGinsTAT c.181_183delCAGinsTAT p.Q61Y RefSeq GRCh38/hg38
NM_001130442 chr11:g.533873_533875delCTGinsATA c.181_183delCAGinsTAT p.Q61Y RefSeq GRCh38/hg38
NM_176795 chr11:g.533873_533875delCTGinsATA c.181_183delCAGinsTAT p.Q61Y RefSeq GRCh38/hg38
NM_005343 chr11:g.533873_533875delCTGinsATA c.181_183delCAGinsTAT p.Q61Y RefSeq GRCh38/hg38
NM_176795.4 chr11:g.533873_533875delCAGinsTAT c.181_183delCAGinsTAT p.Q61Y RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533873_533875delCAGinsTAT c.181_183delCAGinsTAT p.Q61Y RefSeq GRCh38/hg38
NM_005343.3 chr11:g.533873_533875delCAGinsTAT c.181_183delCAGinsTAT p.Q61Y RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533873_533875delCAGinsTAT c.181_183delCAGinsTAT p.Q61Y RefSeq GRCh38/hg38
NM_176795.5 chr11:g.533873_533875delCAGinsTAT c.181_183delCAGinsTAT p.Q61Y RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References