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Gene | HRAS |
Variant | Q61G |
Impact List | missense |
Protein Effect | loss of function |
Gene Variant Descriptions | HRAS Q61G does not lie within any known functional domains of the Hras protein (UniProt.org). Q61G results in decreased Hras GTPase activity and leads to transformation of cells in culture (PMID: 3510078). |
Associated Drug Resistance | |
Category Variants Paths |
HRAS mutant HRAS act mut HRAS Q61G HRAS mutant HRAS Q61X HRAS Q61G |
Transcript | NM_005343.4 |
gDNA | chr11:g.533874_533875delCAinsGG |
cDNA | c.181_182delCAinsGG |
Protein | p.Q61G |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_176795 | chr11:g.533874_533875delTGinsCC | c.181_182delCAinsGG | p.Q61G | RefSeq | GRCh38/hg38 |
NM_005343.3 | chr11:g.533874_533875delCAinsGG | c.181_182delCAinsGG | p.Q61G | RefSeq | GRCh38/hg38 |
NM_176795.5 | chr11:g.533874_533875delCAinsGG | c.181_182delCAinsGG | p.Q61G | RefSeq | GRCh38/hg38 |
NM_001130442.2 | chr11:g.533874_533875delCAinsGG | c.181_182delCAinsGG | p.Q61G | RefSeq | GRCh38/hg38 |
NM_005343 | chr11:g.533874_533875delTGinsCC | c.181_182delCAinsGG | p.Q61G | RefSeq | GRCh38/hg38 |
NM_001130442 | chr11:g.533874_533875delTGinsCC | c.181_182delCAinsGG | p.Q61G | RefSeq | GRCh38/hg38 |
NM_001130442.3 | chr11:g.533874_533875delCAinsGG | c.181_182delCAinsGG | p.Q61G | RefSeq | GRCh38/hg38 |
NM_176795.4 | chr11:g.533874_533875delCAinsGG | c.181_182delCAinsGG | p.Q61G | RefSeq | GRCh38/hg38 |
NM_005343.4 | chr11:g.533874_533875delCAinsGG | c.181_182delCAinsGG | p.Q61G | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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