Gene Variant Detail

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Gene HRAS
Variant G12Y
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions HRAS G12Y does not lie within any known functional domains of the Hras protein (UniProt.org). G12Y is transforming in cultured cells (PMID: 6092966), and can be predicted to lead to a loss of Hras protein function and activation of downstream signaling based on the effects of other HRAS G12 mutations.
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS G12Y

HRAS mutant HRAS G12X HRAS G12Y

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Transcript NM_005343.4
gDNA chr11:g.534288_534289delGGinsTA
cDNA c.34_35delGGinsTA
Protein p.G12Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001130442.2 chr11:g.534288_534289delGGinsTA c.34_35delGGinsTA p.G12Y RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.534288_534289delGGinsTA c.34_35delGGinsTA p.G12Y RefSeq GRCh38/hg38
NM_001130442 chr11:g.534288_534289delCCinsTA c.34_35delGGinsTA p.G12Y RefSeq GRCh38/hg38
NM_005343.3 chr11:g.534288_534289delGGinsTA c.34_35delGGinsTA p.G12Y RefSeq GRCh38/hg38
NM_176795 chr11:g.534288_534289delCCinsTA c.34_35delGGinsTA p.G12Y RefSeq GRCh38/hg38
NM_005343 chr11:g.534288_534289delCCinsTA c.34_35delGGinsTA p.G12Y RefSeq GRCh38/hg38
NM_005343.4 chr11:g.534288_534289delGGinsTA c.34_35delGGinsTA p.G12Y RefSeq GRCh38/hg38
NM_176795.4 chr11:g.534288_534289delGGinsTA c.34_35delGGinsTA p.G12Y RefSeq GRCh38/hg38
NM_176795.5 chr11:g.534288_534289delGGinsTA c.34_35delGGinsTA p.G12Y RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries