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Gene | HRAS |
Variant | G12F |
Impact List | missense |
Protein Effect | loss of function - predicted |
Gene Variant Descriptions | HRAS G12F does not lie within any known functional domains of the Hras protein (UniProt.org). G12F is transforming in culture (PMID: 6092966), and is predicted to result in a loss of Hras protein function based on the effect of KRAS G12F, which results in decreased Kras GTPase activity and activation of downstream Mapk signaling (PMID: 11668624). |
Associated Drug Resistance | |
Category Variants Paths |
HRAS mutant HRAS act mut HRAS G12F HRAS mutant HRAS G12X HRAS G12F |
Transcript | NM_005343.4 |
gDNA | chr11:g.534288_534289delGGinsTT |
cDNA | c.34_35delGGinsTT |
Protein | p.G12F |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |