HRAS G12K
Gene Variant Detail

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Gene HRAS
Variant G12K
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions HRAS G12K does not lie within any known functional domains of the Hras protein (UniProt.org). G12K is transforming in cultured cells (PMID: 6092966), and can be predicted to lead to a loss of Hras protein function and activation of downstream signaling based on the effects of other HRAS G12 mutations.
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS G12K

HRAS mutant HRAS G12X HRAS G12K

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Transcript NM_005343.4
gDNA chr11:g.534287_534289delGGCinsAAG
cDNA c.34_36delGGCinsAAG
Protein p.G12K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_176795 chr11:g.534287_534289delGCCinsCTT c.34_36delGGCinsAAG p.G12K RefSeq GRCh38/hg38
NM_176795.4 chr11:g.534287_534289delGGCinsAAG c.34_36delGGCinsAAG p.G12K RefSeq GRCh38/hg38
NM_005343.3 chr11:g.534287_534289delGGCinsAAG c.34_36delGGCinsAAG p.G12K RefSeq GRCh38/hg38
NM_001130442 chr11:g.534287_534289delGCCinsCTT c.34_36delGGCinsAAG p.G12K RefSeq GRCh38/hg38
NM_005343 chr11:g.534287_534289delGCCinsCTT c.34_36delGGCinsAAG p.G12K RefSeq GRCh38/hg38
NM_005343.4 chr11:g.534287_534289delGGCinsAAG c.34_36delGGCinsAAG p.G12K RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.534287_534289delGGCinsAAG c.34_36delGGCinsAAG p.G12K RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.534287_534289delGGCinsAAG c.34_36delGGCinsAAG p.G12K RefSeq GRCh38/hg38
NM_176795.5 chr11:g.534287_534289delGGCinsAAG c.34_36delGGCinsAAG p.G12K RefSeq GRCh38/hg38

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Molecular Profile Protein Effect Treatment Approaches
HRAS G12K loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)