Gene Variant Detail

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Gene HRAS
Variant G12Q
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions HRAS G12Q does not lie within any known functional domains of the Hras protein (UniProt.org). G12Q is transforming in cultured cells (PMID: 6092966), and can be predicted to lead to a loss of Hras protein function and activation of downstream signaling based on the effects of other HRAS G12 mutations.
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS G12Q

HRAS mutant HRAS G12X HRAS G12Q

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Transcript NM_005343.4
gDNA chr11:g.534287_534289delGGCinsCAA
cDNA c.34_36delGGCinsCAA
Protein p.G12Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005343.4 chr11:g.534287_534289delGGCinsCAA c.34_36delGGCinsCAA p.G12Q RefSeq GRCh38/hg38
NM_001130442 chr11:g.534287_534289delGCCinsTTG c.34_36delGGCinsCAA p.G12Q RefSeq GRCh38/hg38
NM_005343.3 chr11:g.534287_534289delGGCinsCAA c.34_36delGGCinsCAA p.G12Q RefSeq GRCh38/hg38
NM_005343 chr11:g.534287_534289delGCCinsTTG c.34_36delGGCinsCAA p.G12Q RefSeq GRCh38/hg38
NM_176795 chr11:g.534287_534289delGCCinsTTG c.34_36delGGCinsCAA p.G12Q RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.534287_534289delGGCinsCAA c.34_36delGGCinsCAA p.G12Q RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.534287_534289delGGCinsCAA c.34_36delGGCinsCAA p.G12Q RefSeq GRCh38/hg38
NM_176795.4 chr11:g.534287_534289delGGCinsCAA c.34_36delGGCinsCAA p.G12Q RefSeq GRCh38/hg38
NM_176795.5 chr11:g.534287_534289delGGCinsCAA c.34_36delGGCinsCAA p.G12Q RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References