HRAS G13T
Gene Variant Detail

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Gene HRAS
Variant G13T
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions HRAS G13T is hotspot mutation that lies within the GTP-binding domain of the Hras protein (UniProt.org). G13T results in increased Hras GTPase activity and loss of response to GTPase-activating proteins, leading to transformation in Xenopus oocytes (PMID: 8430333).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS G13T

HRAS mutant HRAS G13X HRAS G13T

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Transcript NM_005343.4
gDNA chr11:g.534285_534286delGGinsAC
cDNA c.37_38delGGinsAC
Protein p.G13T
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.