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Gene | HRAS |
Variant | G13T |
Impact List | missense |
Protein Effect | gain of function |
Gene Variant Descriptions | HRAS G13T is hotspot mutation that lies within the GTP-binding domain of the Hras protein (UniProt.org). G13T results in increased Hras GTPase activity and loss of response to GTPase-activating proteins, leading to transformation in Xenopus oocytes (PMID: 8430333). |
Associated Drug Resistance | |
Category Variants Paths |
HRAS mutant HRAS act mut HRAS G13T HRAS mutant HRAS G13X HRAS G13T |
Transcript | NM_005343.4 |
gDNA | chr11:g.534285_534286delGGinsAC |
cDNA | c.37_38delGGinsAC |
Protein | p.G13T |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |