Gene Variant Detail

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Gene HRAS
Variant G13T
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions HRAS G13T is hotspot mutation that lies within the GTP-binding domain of the Hras protein (UniProt.org). G13T results in increased Hras GTPase activity and loss of response to GTPase-activating proteins, leading to transformation in Xenopus oocytes (PMID: 8430333).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS G13T

HRAS mutant HRAS G13X HRAS G13T

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Transcript NM_005343.4
gDNA chr11:g.534285_534286delGGinsAC
cDNA c.37_38delGGinsAC
Protein p.G13T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001130442.2 chr11:g.534285_534286delGGinsAC c.37_38delGGinsAC p.G13T RefSeq GRCh38/hg38
NM_005343 chr11:g.534285_534286delCCinsGT c.37_38delGGinsAC p.G13T RefSeq GRCh38/hg38
NM_176795.4 chr11:g.534285_534286delGGinsAC c.37_38delGGinsAC p.G13T RefSeq GRCh38/hg38
NM_176795 chr11:g.534285_534286delCCinsGT c.37_38delGGinsAC p.G13T RefSeq GRCh38/hg38
NM_005343.3 chr11:g.534285_534286delGGinsAC c.37_38delGGinsAC p.G13T RefSeq GRCh38/hg38
NM_176795.5 chr11:g.534285_534286delGGinsAC c.37_38delGGinsAC p.G13T RefSeq GRCh38/hg38
NM_001130442 chr11:g.534285_534286delCCinsGT c.37_38delGGinsAC p.G13T RefSeq GRCh38/hg38
NM_005343.4 chr11:g.534285_534286delGGinsAC c.37_38delGGinsAC p.G13T RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.534285_534286delGGinsAC c.37_38delGGinsAC p.G13T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
HRAS G13T gain of function MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor PIK3CB inhibitor PIK3CD inhibitor PIK3CG inhibitor RAS Inhibitor (Pan)