FLT3 F590_F605dup
Gene Variant Detail

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Gene FLT3
Variant F590_F605dup
Impact List duplication
Protein Effect gain of function
Gene Variant Descriptions FLT3 F590_F605dup indicates the insertion of 16 duplicate amino acids, phenylalanine (F)-590 through phenylalanine (F)-605, in the juxtamembrane domain of the Flt3 protein (PMID: 11756186). F590_F605dup results in constitutive phosphorylation of Flt3, activation of Stat5 and Erk signaling, and transformation of cells in culture (PMID: 10698507).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 exon 14 ins FLT3 F590_F605dup

FLT3 mutant FLT3 exon14 FLT3 exon 14 ins FLT3 F590_F605dup

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Transcript NM_004119.3
gDNA chr13:g.28034104_28034151
cDNA c.1768_1815
Protein p.F590_F605
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.3 chr13:g.28034104_28034151 c.1768_1815 p.F590_F605 RefSeq GRCh38/hg38
NM_004119 chr13:g.28034112_28034113insCTTAAGGTCATACTCATACTCCCTAAAGTCTACATAAAAAAACTCCCA c.1815_1816insTTTTATGTAGACTTTAGGGAGTATGAGTATGACCTTAAGTGGGAGTTT p.F590_F605dup RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References