KDR G539R
Gene Variant Detail

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Gene KDR
Variant G539R
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions KDR (VEGFR2) G539R lies within Ig-like C2-type domain 5 of the Kdr (Vegfr2) protein (UniProt.org). G539R is associated with increased expression of Kdr (Vegfr2) and increased ligand-dependent Erk phosphorylation in cell culture (PMID: 30761385), and therefore, is predicted to lead to a gain of Kdr (Vegfr2) protein function.
Associated Drug Resistance
Category Variants Paths

KDR mutant KDR act mut KDR G539R

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Transcript NM_002253.4
gDNA chr4:g.55105862C>T
cDNA c.1615G>A
Protein p.G539R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002253.3 chr4:g.55105862C>T c.1615G>A p.G539R RefSeq GRCh38/hg38
NM_002253 chr4:g.55105862C>T c.1615G>A p.G539R RefSeq GRCh38/hg38
NM_002253.4 chr4:g.55105862C>T c.1615G>A p.G539R RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
KDR G539R gain of function - predicted