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Gene APC
Variant N1455Ifs*18
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions APC N1455Ifs*18 indicates a shift in the reading frame starting at amino acid 1455 and terminating 18 residues downstream causing a premature truncation of the 2843 amino acid Apc protein (UniProt.org). N1455Ifs*18 has not been characterized, however, due to the effects of other truncation mutations downstream of N1455 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC N1455fs APC N1455Ifs*18

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Transcript NM_000038.6
gDNA chr5:g.112839958delA
cDNA c.4364delA
Protein p.N1455Ifs*18
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001127510 chr5:g.112839953delT c.4359delT p.N1455Ifs*18 RefSeq GRCh38/hg38
NM_001127511.3 chr5:g.112840011_112840012insTCCCCCCCCCAAA c.4363_4364insTCCCCCCCCCAAA p.N1455Ifs*18 RefSeq GRCh38/hg38
NM_000038 chr5:g.112839953delT c.4359delT p.N1455Ifs*18 RefSeq GRCh38/hg38
NM_001127511 chr5:g.112840011_112840012insTCCCCCCCCCCTT c.4363_4364insTCCCCCCCCCCTT p.N1455Ifs*18 RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112839958delA c.4364delA p.N1455Ifs*18 RefSeq GRCh38/hg38
NM_001354902.1 chr5:g.(112840230_112840286) c.(4363_4419) p.N1455Ifs*18 RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112839958delA c.4364delA p.N1455Ifs*18 RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112839958delA c.4364delA p.N1455Ifs*18 RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112839958delA c.4364delA p.N1455Ifs*18 RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.112839958delA c.4364delA p.N1455Ifs*18 RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112839958delA c.4364delA p.N1455Ifs*18 RefSeq GRCh38/hg38
NM_001354902.2 chr5:g.(112840230_112840286) c.(4363_4419) p.N1455Ifs*18 RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112839958delA c.4364delA p.N1455Ifs*18 RefSeq GRCh38/hg38
NM_001127511.2 chr5:g.112840011_112840012insTCCCCCCCCCAAA c.4363_4364insTCCCCCCCCCAAA p.N1455Ifs*18 RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References