We’re improving your experience!

Starting April 21, you’ll be asked to log in or sign up for a free account after viewing 10 content pages each month.

Don’t worry—creating an account is quick and easy, and it comes with added benefits! Once logged in, you’ll not only continue accessing the content you already enjoy, but you’ll also unlock exclusive features like interactive donut plots for variant protein effects and variant impacts across the gene.

Stay tuned for these updates, and thank you for being part of our community!

TP53 R213L - Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene TP53
Variant R213L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 R213L lies within the DNA-binding domain of the Tp53 protein (UniProt.org). R213L results in decreased transactivation in a yeast assay (PMID: 37838351), but has not been fully biochemically characterized and therefore, its effect on Tp53 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon6 TP53 R213L

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_000546.6
gDNA chr17:g.7674893C>A
cDNA c.638G>T
Protein p.R213L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000546.6 chr17:g.7674893C>A c.638G>T p.R213L RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674893C>A c.638G>T p.R213L RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674893C>A c.638G>T p.R213L RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674893C>A c.638G>T p.R213L RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674893C>A c.638G>T p.R213L RefSeq GRCh38/hg38
NM_001126113 chr17:g.7674893C>A c.638G>T p.R213L RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674893C>A c.638G>T p.R213L RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674893C>A c.638G>T p.R213L RefSeq GRCh38/hg38
NM_001126112 chr17:g.7674893C>A c.638G>T p.R213L RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7674893C>A c.638G>T p.R213L RefSeq GRCh38/hg38
NM_001126114 chr17:g.7674893C>A c.638G>T p.R213L RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674893C>A c.638G>T p.R213L RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674893C>A c.638G>T p.R213L RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7674893C>A c.638G>T p.R213L RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674893C>A c.638G>T p.R213L RefSeq GRCh38/hg38
NM_000546 chr17:g.7674893C>A c.638G>T p.R213L RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674893C>A c.638G>T p.R213L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
TP53 R213L unknown