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Gene | TP53 |
Variant | R213L |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | TP53 R213L lies within the DNA-binding domain of the Tp53 protein (UniProt.org). R213L results in decreased transactivation in a yeast assay (PMID: 37838351), but has not been fully biochemically characterized and therefore, its effect on Tp53 protein function is unknown. |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon6 TP53 R213L |
Transcript | NM_000546.6 |
gDNA | chr17:g.7674893C>A |
cDNA | c.638G>T |
Protein | p.R213L |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |