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Gene IDH2
Variant T146fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions IDH2 T146fs results in a change in the amino acid sequence of the Idh2 protein beginning at aa 146 of 452, likely resulting in premature truncation of the functional protein (UniProt.org). Due to the loss of sites critical for catalysis (UniProt.org), T146fs is predicted to lead to a loss of Idh2 protein function.
Associated Drug Resistance
Category Variants Paths

IDH2 mutant IDH2 inact mut IDH2 T146fs

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Transcript NM_002168.4
gDNA chr15:g.(90088685_90088686)
cDNA c.(436_435)
Protein p.T146fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001290114 chr15:g.(90087253_90087254) c.(436_435) p.T146fs RefSeq GRCh38/hg38
NM_001290114.1 chr15:g.(90087253_90087254) c.(436_435) p.T146fs RefSeq GRCh38/hg38
NM_002168.3 chr15:g.(90088685_90088686) c.(436_435) p.T146fs RefSeq GRCh38/hg38
NM_001290114.2 chr15:g.(90087253_90087254) c.(436_435) p.T146fs RefSeq GRCh38/hg38
NM_002168.4 chr15:g.(90088685_90088686) c.(436_435) p.T146fs RefSeq GRCh38/hg38
NM_002168 chr15:g.(90088685_90088686) c.(436_435) p.T146fs RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References