KDR L840F
Gene Variant Detail

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Gene KDR
Variant L840F
Impact List missense
Protein Effect unknown
Gene Variant Descriptions KDR (VEGFR2) L840F lies within the protein kinase domain of the Kdr (Vegfr2) protein (UniProt.org). L840F is associated with resistance to Kdr (Vegfr2) inhibitors (PMID: 29588308), and results in reduced kinase activity in culture, but demonstrates Erk activation and tumor formation in mouse models (PMID: 29588308), and therefore, its effect on Kdr (Vegfr2) protein function is unknown.
Associated Drug Resistance Y
Category Variants Paths

KDR mutant KDR L840F

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Transcript NM_002253.4
gDNA chr4:g.55097758G>A
cDNA c.2518C>T
Protein p.L840F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002253.3 chr4:g.55097758G>A c.2518C>T p.L840F RefSeq GRCh38/hg38
NM_002253.4 chr4:g.55097758G>A c.2518C>T p.L840F RefSeq GRCh38/hg38
NM_002253 chr4:g.55097758G>A c.2518C>T p.L840F RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References