Gene Variant Detail

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Gene STK11
Variant P281Pfs*4
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions STK11 P281Pfs*4 indicates a shift in the reading frame starting at amino acid 281 and terminating 4 residues downstream, causing a premature truncation of the 433 amino acid Stk11 protein (UniProt.org). P281Pfs*4 results in decreased Tp53 activity in culture (PMID: 30092773), and therefore, is predicted to lead to a loss of Stk11 protein function.
Associated Drug Resistance
Category Variants Paths

STK11 mutant STK11 inact mut STK11 P281fs STK11 P281Pfs*4

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Transcript NM_000455.5
gDNA chr19:g.(1221319_1221333)
cDNA c.(841_855)
Protein p.P281Pfs*4
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000455.4 chr19:g.(1221319_1221333) c.(841_855) p.P281Pfs*4 RefSeq GRCh38/hg38
NM_001407255.1 chr19:g.(1221319_1221333) c.(841_855) p.P281Pfs*4 RefSeq GRCh38/hg38
XM_005259618 chr19:g.(1221319_1221333) c.(841_855) p.P281Pfs*4 RefSeq GRCh38/hg38
NM_000455.5 chr19:g.(1221319_1221333) c.(841_855) p.P281Pfs*4 RefSeq GRCh38/hg38
XM_005259617 chr19:g.(1221319_1221333) c.(841_855) p.P281Pfs*4 RefSeq GRCh38/hg38
XM_005259617.3 chr19:g.(1221319_1221333) c.(841_855) p.P281Pfs*4 RefSeq GRCh38/hg38
NM_000455 chr19:g.(1221319_1221333) c.(841_855) p.P281Pfs*4 RefSeq GRCh38/hg38
XM_005259618.3 chr19:g.(1221319_1221333) c.(841_855) p.P281Pfs*4 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
STK11 P281Pfs*4 loss of function - predicted mTOR Inhibitor mTORC1 Inhibitor