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Gene APC
Variant A952Qfs*10
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions APC A952Qfs*10 indicates a shift in the reading frame starting at amino acid 952 and terminating 10 residues downstream causing a premature truncation of the 2843 amino acid Apc protein (UniProt.org). A952Qfs*10 has not been characterized, however, due to the effects of other truncation mutations downstream of A952 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC A952Qfs*10

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Transcript NM_000038.6
gDNA chr5:g.112838448_112838449delGC
cDNA c.2854_2855delGC
Protein p.A952Qfs*10
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354901.2 chr5:g.112838624_112838625insCACCCCCCCCCAA c.2853_2854insCACCCCCCCCCAA p.A952Qfs*10 RefSeq GRCh38/hg38
NM_001127510 chr5:g.112838447_112838448delTG c.2853_2854delTG p.A952Qfs*10 RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112838448_112838449delGC c.2854_2855delGC p.A952Qfs*10 RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112838448_112838449delGC c.2854_2855delGC p.A952Qfs*10 RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112838448_112838449delGC c.2854_2855delGC p.A952Qfs*10 RefSeq GRCh38/hg38
NM_000038 chr5:g.112838447_112838448delTG c.2853_2854delTG p.A952Qfs*10 RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.112838448_112838449delGC c.2854_2855delGC p.A952Qfs*10 RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112838448_112838449delGC c.2854_2855delGC p.A952Qfs*10 RefSeq GRCh38/hg38
NM_001407453.1 chr5:g.112838624_112838625insCACCCCCCCCCAA c.2853_2854insCACCCCCCCCCAA p.A952Qfs*10 RefSeq GRCh38/hg38
NM_001354901.1 chr5:g.112838624_112838625insCACCCCCCCCCAA c.2853_2854insCACCCCCCCCCAA p.A952Qfs*10 RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112838448_112838449delGC c.2854_2855delGC p.A952Qfs*10 RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112838448_112838449delGC c.2854_2855delGC p.A952Qfs*10 RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References