STK11 A218Sfs*42
Gene Variant Detail

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Gene STK11
Variant A218Sfs*42
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions STK11 A218Sfs*42 indicates a shift in the reading frame starting at amino acid 218 and terminating 42 residues downstream, causing a premature truncation of the 433 amino acid Stk11 protein (UniProt.org). A218Sfs*42 has not been characterized however, due to the effects of other truncation mutations downstream of A218 (PMID: 23612973), is predicted to lead to a loss of Stk11 protein function.
Associated Drug Resistance
Category Variants Paths

STK11 mutant STK11 inact mut STK11 A218Sfs*42

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Transcript NM_000455.5
gDNA chr19:g.(1220635_1221258)
cDNA c.(652_780)
Protein p.A218Sfs*42
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005259617 chr19:g.(1220635_1221258) c.(652_780) p.A218Sfs*42 RefSeq GRCh38/hg38
XM_005259617.3 chr19:g.(1220635_1221258) c.(652_780) p.A218Sfs*42 RefSeq GRCh38/hg38
NM_001407255.1 chr19:g.(1220635_1221258) c.(652_780) p.A218Sfs*42 RefSeq GRCh38/hg38
XM_005259618 chr19:g.(1220635_1221258) c.(652_780) p.A218Sfs*42 RefSeq GRCh38/hg38
NM_000455.5 chr19:g.(1220635_1221258) c.(652_780) p.A218Sfs*42 RefSeq GRCh38/hg38
XM_005259618.3 chr19:g.(1220635_1221258) c.(652_780) p.A218Sfs*42 RefSeq GRCh38/hg38
NM_000455 chr19:g.(1220635_1221258) c.(652_780) p.A218Sfs*42 RefSeq GRCh38/hg38
NM_000455.4 chr19:g.(1220635_1221258) c.(652_780) p.A218Sfs*42 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References