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Gene TET2
Variant F1377A
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions TET2 F1377A lies within the catalytic domain of the Tet2 protein (PMID: 24315485). F1377A results in loss of Tet2 catalytic activity in an in vitro assay (PMID: 30028600), and therefore, is predicted to lead to a loss of Tet2 protein function.
Associated Drug Resistance
Category Variants Paths

TET2 mutant TET2 inact mut TET2 F1377A

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Transcript NM_001127208.3
gDNA chr4:g.105269694_105269695delTTinsGC
cDNA c.4129_4130delTTinsGC
Protein p.F1377A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001127208 chr4:g.105269694_105269695delTTinsGC c.4129_4130delTTinsGC p.F1377A RefSeq GRCh38/hg38
XM_005263082 chr4:g.105269694_105269695delTTinsGC c.4129_4130delTTinsGC p.F1377A RefSeq GRCh38/hg38
XM_005263082.3 chr4:g.105269694_105269695delTTinsGC c.4129_4130delTTinsGC p.F1377A RefSeq GRCh38/hg38
XM_024454103.2 chr4:g.105269694_105269695delTTinsGC c.4129_4130delTTinsGC p.F1377A RefSeq GRCh38/hg38
XM_005263082.4 chr4:g.105269694_105269695delTTinsGC c.4129_4130delTTinsGC p.F1377A RefSeq GRCh38/hg38
NM_001127208.2 chr4:g.105269694_105269695delTTinsGC c.4129_4130delTTinsGC p.F1377A RefSeq GRCh38/hg38
XM_024454102.2 chr4:g.105269694_105269695delTTinsGC c.4129_4130delTTinsGC p.F1377A RefSeq GRCh38/hg38
XM_024454102.1 chr4:g.105269694_105269695delTTinsGC c.4129_4130delTTinsGC p.F1377A RefSeq GRCh38/hg38
NM_001127208.3 chr4:g.105269694_105269695delTTinsGC c.4129_4130delTTinsGC p.F1377A RefSeq GRCh38/hg38
XM_024454103.1 chr4:g.105269694_105269695delTTinsGC c.4129_4130delTTinsGC p.F1377A RefSeq GRCh38/hg38

Filtering

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References