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Gene STK11
Variant F298L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions STK11 F298L lies within the protein kinase domain of the Stk11 protein (UniProt.org). F298L has been identified in the scientific literature (PMID: 27615706), but has not been biochemically characterized and therefore, its effect on Stk11 protein function is unknown (PubMed, May 2024).
Associated Drug Resistance
Category Variants Paths

STK11 mutant STK11 F298L

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Transcript NM_000455.5
gDNA chr19:g.1221978T>C
cDNA c.892T>C
Protein p.F298L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000455.4 chr19:g.1221978T>C c.892T>C p.F298L RefSeq GRCh38/hg38
NM_001407255.1 chr19:g.1221978T>C c.892T>C p.F298L RefSeq GRCh38/hg38
XM_005259618 chr19:g.1221978T>C c.892T>C p.F298L RefSeq GRCh38/hg38
XM_005259617.3 chr19:g.1221978T>C c.892T>C p.F298L RefSeq GRCh38/hg38
NM_000455.5 chr19:g.1221978T>C c.892T>C p.F298L RefSeq GRCh38/hg38
XM_005259618.3 chr19:g.1221978T>C c.892T>C p.F298L RefSeq GRCh38/hg38
NM_000455 chr19:g.1221978T>C c.892T>C p.F298L RefSeq GRCh38/hg38
XM_005259617 chr19:g.1221978T>C c.892T>C p.F298L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
STK11 F298L pituitary carcinoma predicted - sensitive Everolimus + Radiotherapy Case Reports/Case Series Actionable In a clinical case study, a patient with adenocorticotropic pituitary carcinoma harboring STK11 F298L demonstrated stable disease and clinical benefit for greater than 6 months following treatment with Afinitor (everolimus), along with radiotherapy (PMID: 27615706). 27615706