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HRAS G12S - Gene Variant Detail

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Gene HRAS
Variant G12S
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions HRAS G12S does not lie within any known functional domains of the Hras protein (UniProt.org). G12S results in decreased Hras GTPase activity, loss of response to GTPase-activating proteins, leading to activation of downstream signaling pathways and transformation of cultured cells (PMID: 24224811, PMID: 21850009, PMID: 6330729).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS act mut HRAS G12S

HRAS mutant HRAS G12X HRAS G12S

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Transcript NM_005343.4
gDNA chr11:g.534289C>T
cDNA c.34G>A
Protein p.G12S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_176795.5 chr11:g.534289C>T c.34G>A p.G12S RefSeq GRCh38/hg38
NM_005343 chr11:g.534289C>T c.34G>A p.G12S RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.534289C>T c.34G>A p.G12S RefSeq GRCh38/hg38
NM_176795.4 chr11:g.534289C>T c.34G>A p.G12S RefSeq GRCh38/hg38
NM_176795 chr11:g.534289C>T c.34G>A p.G12S RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.534289C>T c.34G>A p.G12S RefSeq GRCh38/hg38
NM_001130442 chr11:g.534289C>T c.34G>A p.G12S RefSeq GRCh38/hg38
NM_005343.4 chr11:g.534289C>T c.34G>A p.G12S RefSeq GRCh38/hg38
NM_005343.3 chr11:g.534289C>T c.34G>A p.G12S RefSeq GRCh38/hg38

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05638698 Phase II Balstilimab + QS21 + TG01 QS21 + TG01 Tg01 Vaccine / Qs-21 Stimulon™ With Or Without Balstilimab As Maintenance Therapy Following Adjuvant Chemotherapy In Patients With Resected Pancreatic Cancer (TESLA) Active, not recruiting USA 0