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Gene | TP53 |
Variant | R267W |
Impact List | missense |
Protein Effect | loss of function |
Gene Variant Descriptions | TP53 R267W lies within the DNA-binding domain of the Tp53 protein (PMID: 15510160). R267W results in decreased Tp53 transcription activity in a reporter assay, reduced DNA binding, and attenuated ability to induce apoptosis in cell culture (PMID: 24076587). |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon8 TP53 R267W TP53 mutant TP53 inact mut TP53 R267W |
Transcript | NM_000546.6 |
gDNA | chr17:g.7673821G>A |
cDNA | c.799C>T |
Protein | p.R267W |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |