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Gene APC
Variant W421*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions APC W421* results in a premature truncation of the Apc protein at amino acid 421 of 2843 (UniProt.org). W421* has not been characterized, however, due to the effects of other truncation mutations downstream of W421 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC W421*

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Transcript NM_000038.6
gDNA chr5:g.112819294G>A
cDNA c.1262G>A
Protein p.W421*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407447.1 chr5:g.112819294G>A c.1262G>A p.W421* RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112819294G>A c.1262G>A p.W421* RefSeq GRCh38/hg38
NM_000038 chr5:g.112819294G>A c.1262G>A p.W421* RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112819294G>A c.1262G>A p.W421* RefSeq GRCh38/hg38
NM_001354896.2 chr5:g.112819294G>A c.1262G>A p.W421* RefSeq GRCh38/hg38
NM_001407448.1 chr5:g.112819294G>A c.1262G>A p.W421* RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112819294G>A c.1262G>A p.W421* RefSeq GRCh38/hg38
NM_001354896.1 chr5:g.112819294G>A c.1262G>A p.W421* RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112819294G>A c.1262G>A p.W421* RefSeq GRCh38/hg38
NM_001407449.1 chr5:g.112819294G>A c.1262G>A p.W421* RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112819294G>A c.1262G>A p.W421* RefSeq GRCh38/hg38
NM_001127510 chr5:g.112819294G>A c.1262G>A p.W421* RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.112819294G>A c.1262G>A p.W421* RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112819294G>A c.1262G>A p.W421* RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
APC W421* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor