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Gene APC
Variant E868*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions APC E868* results in a premature truncation of the Apc protein at amino acid 868 of 2843 (UniProt.org). E868* has not been characterized, however, due to the effects of other truncation mutations downstream of E868 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC E868*

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Transcript NM_000038.6
gDNA chr5:g.112838196G>T
cDNA c.2602G>T
Protein p.E868*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000038.5 chr5:g.112838196G>T c.2602G>T p.E868* RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112838196G>T c.2602G>T p.E868* RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112838196G>T c.2602G>T p.E868* RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112838196G>T c.2602G>T p.E868* RefSeq GRCh38/hg38
NM_001127510 chr5:g.112838196G>T c.2602G>T p.E868* RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112838196G>T c.2602G>T p.E868* RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112838196G>T c.2602G>T p.E868* RefSeq GRCh38/hg38
NM_001407470.1 chr5:g.112839045G>T c.2602G>T p.E868* RefSeq GRCh38/hg38
NM_001354898.2 chr5:g.112838271G>T c.2602G>T p.E868* RefSeq GRCh38/hg38
NM_001354906.2 chr5:g.112839045G>T c.2602G>T p.E868* RefSeq GRCh38/hg38
NM_001354898.1 chr5:g.112838271G>T c.2602G>T p.E868* RefSeq GRCh38/hg38
NM_000038 chr5:g.112838196G>T c.2602G>T p.E868* RefSeq GRCh38/hg38
NM_001354906.1 chr5:g.112839045G>T c.2602G>T p.E868* RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.112838196G>T c.2602G>T p.E868* RefSeq GRCh38/hg38

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Sorting

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Molecular Profile Protein Effect Treatment Approaches
APC E868* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor