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Gene APC
Variant M1525Lfs*39
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions APC M1525Lfs*39 indicates a shift in the reading frame starting at amino acid 1525 and terminating 39 residues downstream causing a premature truncation of the 2843 amino acid Apc protein (UniProt.org). M1525Lfs*39 has not been characterized, however, due to the effects of other truncation mutations downstream of M1525 (PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC M1525Lfs*39

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Transcript NM_000038.6
gDNA chr5:g.112840167_112840170delATGC
cDNA c.4573_4576delATGC
Protein p.M1525Lfs*39
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407450.1 chr5:g.112840167_112840170delATGC c.4573_4576delATGC p.M1525Lfs*39 RefSeq GRCh38/hg38
NM_000038 chr5:g.112840166_112840169delAATG c.4572_4575delAATG p.M1525Lfs*39 RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112840167_112840170delATGC c.4573_4576delATGC p.M1525Lfs*39 RefSeq GRCh38/hg38
NM_001127510 chr5:g.112840166_112840169delAATG c.4572_4575delAATG p.M1525Lfs*39 RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112840167_112840170delATGC c.4573_4576delATGC p.M1525Lfs*39 RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112840167_112840170delATGC c.4573_4576delATGC p.M1525Lfs*39 RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112840167_112840170delATGC c.4573_4576delATGC p.M1525Lfs*39 RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112840167_112840170delATGC c.4573_4576delATGC p.M1525Lfs*39 RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112840167_112840170delATGC c.4573_4576delATGC p.M1525Lfs*39 RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References