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Gene APC
Variant T621Lfs*9
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions APC T621Lfs*9 indicates a shift in the reading frame starting at amino acid 621 and terminating 9 residues downstream causing a premature truncation of the 2843 amino acid Apc protein (UniProt.org). T621Lfs*9 has not been characterized, however, due to the effects of other truncation mutations downstream of T621 (PMID: 18199528, PMID: 10346819), is predicted to lead to a loss of Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC inact mut APC T621Lfs*9

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Transcript NM_000038.6
gDNA chr5:g.112835068delA
cDNA c.1861delA
Protein p.T621Lfs*9
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000038.6 chr5:g.112835068delA c.1861delA p.T621Lfs*9 RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112835068delA c.1861delA p.T621Lfs*9 RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112835068delA c.1861delA p.T621Lfs*9 RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112835068delA c.1861delA p.T621Lfs*9 RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112835068delA c.1861delA p.T621Lfs*9 RefSeq GRCh38/hg38
NM_000038 chr5:g.112835064delT c.1857delT p.T621Lfs*9 RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112835068delA c.1861delA p.T621Lfs*9 RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.112835068delA c.1861delA p.T621Lfs*9 RefSeq GRCh38/hg38
NM_001407451.1 chr5:g.112835088_112835089insCTCCCCCCAA c.1860_1861insCTCCCCCCAA p.T621Lfs*9 RefSeq GRCh38/hg38
NM_001127510 chr5:g.112835064delT c.1857delT p.T621Lfs*9 RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Sorting

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Molecular Profile Protein Effect Treatment Approaches
APC T621Lfs*9 loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor