ERBB3 M91I
Gene Variant Detail

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Gene ERBB3
Variant M91I
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ERBB3 (HER3) M91I lies within the extracellular domain of the Erbb3 (Her3) protein (UniProt.org). M91I has been identified in the scientific literature (PMID: 30709382, PMID: 28388586, PMID: 29338072), but has not been biochemically characterized and therefore, its effect on Erbb3 (Her3) protein function is unknown (PubMed, Jan 2026).
Associated Drug Resistance
Category Variants Paths

ERBB3 mutant ERBB3 M91I

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Transcript NM_001982.4
gDNA chr12:g.56085033G>C
cDNA c.273G>C
Protein p.M91I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001005915 chr12:g.56085033G>C c.273G>C p.M91I RefSeq GRCh38/hg38
NM_001982 chr12:g.56085033G>C c.273G>C p.M91I RefSeq GRCh38/hg38
NM_001982.3 chr12:g.56085033G>C c.273G>C p.M91I RefSeq GRCh38/hg38
NM_001005915.1 chr12:g.56085033G>C c.273G>C p.M91I RefSeq GRCh38/hg38
NM_001005915.1 chr12:g.56085033G>C c.273G>C p.M91I RefSeq GRCh38/hg38
NM_001982.4 chr12:g.56085033G>C c.273G>C p.M91I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB3 M91I bladder carcinoma sensitive Neratinib Preclinical - Cell culture Actionable In a preclinical study, Nerlynx (neratinib) treatment inhibited viability of a bladder carcinoma cell line harboring ERBB3 (HER3) M91I in culture (PMID: 33473169). 33473169
ERBB3 M91I bladder carcinoma resistant Lapatinib Preclinical - Cell culture Actionable In a preclinical study, a bladder carcinoma cell line harboring ERBB3 (HER3) M91I was resistant to Tykerb (lapatinib) in culture (PMID: 33473169). 33473169