PIK3CA F977Y
Gene Variant Detail

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Gene PIK3CA
Variant F977Y
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA F977Y lies within the PI3K/PI4K domain of the Pik3ca protein (UniProt.org). F977Y has been associated with resistance to a PI3K inhibitor in culture (PMID: 30108165), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Aug 2025).
Associated Drug Resistance Y
Category Variants Paths

PIK3CA mutant PIK3CA exon20 PIK3CA F977Y

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Transcript NM_006218.4
gDNA chr3:g.179230370T>A
cDNA c.2930T>A
Protein p.F977Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011512894 chr3:g.179230370T>A c.2930T>A p.F977Y RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179230370T>A c.2930T>A p.F977Y RefSeq GRCh38/hg38
XM_006713658 chr3:g.179230370T>A c.2930T>A p.F977Y RefSeq GRCh38/hg38
NM_006218 chr3:g.179230370T>A c.2930T>A p.F977Y RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179230370T>A c.2930T>A p.F977Y RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179230370T>A c.2930T>A p.F977Y RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179230370T>A c.2930T>A p.F977Y RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179230370T>A c.2930T>A p.F977Y RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA F977Y head and neck squamous cell carcinoma resistant Pictilisib Preclinical - Cell culture Actionable In a preclinical study, a head and neck squamous cell carcinoma cell line harboring PIK3CA F977Y demonstrated resistance to growth inhibition by Pictilisib (GDC-0941) in culture (PMID: 30108165). 30108165