PIK3CA L456R
Gene Variant Detail

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Gene PIK3CA
Variant L456R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA L456R lies within the C2 PI3K-type domain of the Pik3ca protein (UniProt.org). L456R has been identified in sequencing studies (PMID: 25528496, PMID: 30503610), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Feb 2026).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon8 PIK3CA L456R

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Transcript NM_006218.4
gDNA chr3:g.179210301T>G
cDNA c.1367T>G
Protein p.L456R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011512894 chr3:g.179210301T>G c.1367T>G p.L456R RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179210301T>G c.1367T>G p.L456R RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179210301T>G c.1367T>G p.L456R RefSeq GRCh38/hg38
NM_006218 chr3:g.179210301T>G c.1367T>G p.L456R RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179210301T>G c.1367T>G p.L456R RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179210301T>G c.1367T>G p.L456R RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179210301T>G c.1367T>G p.L456R RefSeq GRCh38/hg38
XM_006713658 chr3:g.179210301T>G c.1367T>G p.L456R RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Protein Effect Treatment Approaches
PIK3CA L456R unknown