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Gene | ROS1 |
Variant | L2028M |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | ROS1 L2028M lies within the protein kinase domain of the Ros1 protein (UniProt.org). L2028M has not been characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Mar 2024). |
Associated Drug Resistance | |
Category Variants Paths |
ROS1 mutant ROS1 L2028M |
Transcript | NM_002944.3 |
gDNA | chr6:g.117317196G>T |
cDNA | c.6082C>A |
Protein | p.L2028M |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
XM_011536049 | chr6:g.117317226G>T | c.6082C>A | p.L2028M | RefSeq | GRCh38/hg38 |
XM_011536049.3 | chr6:g.117317226G>T | c.6082C>A | p.L2028M | RefSeq | GRCh38/hg38 |
XM_011536049.2 | chr6:g.117317226G>T | c.6082C>A | p.L2028M | RefSeq | GRCh38/hg38 |
NM_002944.2 | chr6:g.117317196G>T | c.6082C>A | p.L2028M | RefSeq | GRCh38/hg38 |
XM_011536054.2 | chr6:g.117317226G>T | c.6082C>A | p.L2028M | RefSeq | GRCh38/hg38 |
NM_001378902.1 | chr6:g.117317176_117317178delCTTinsATG | c.6082_6084delCTTinsATG | p.L2028M | RefSeq | GRCh38/hg38 |
NM_002944.3 | chr6:g.117317196G>T | c.6082C>A | p.L2028M | RefSeq | GRCh38/hg38 |
XM_011536054.3 | chr6:g.117317226G>T | c.6082C>A | p.L2028M | RefSeq | GRCh38/hg38 |
XM_011536054 | chr6:g.117317226G>T | c.6082C>A | p.L2028M | RefSeq | GRCh38/hg38 |
NM_002944 | chr6:g.117317196G>T | c.6082C>A | p.L2028M | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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