MSH2 negative
Gene Variant Detail

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Gene MSH2
Variant negative
Impact List unknown
Protein Effect loss of function
Gene Variant Descriptions MSH2 negative indicates a lack of expression of the MSH2 mRNA and/or protein.
Associated Drug Resistance
Category Variants Paths

MSH2 mutant MSH2 inact mut MSH2 negative

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No Variant Reference Transcript is Available.
No transcript is Available.

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
MSH2 negative loss of function PD-L1/PD-1 antibody Ipilimumab + Nivolumab
BRAF mut MSH2 neg
MSH2 C822fs MSH2 neg MSH6 T1085fs MSH6 neg
CD274 pos MSH2 E226* MSH2 E580* MSH2 A913fs MSH2 neg MSH6 R361H MSH6 neg