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Gene TP53
Variant G360A
Impact List missense
Protein Effect no effect
Gene Variant Descriptions TP53 G360A lies within the CARM1, HIPK1, HIPK2, and USP7 interacting regions of the Tp53 protein (UniProt.org). G360A demonstrates DNA-binding activity, induction of apoptosis, and activation of STAT4 mRNA expression to similar levels of wild-type Tp53 in culture (PMID: 24076587).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon10 TP53 G360A

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Transcript NM_000546.6
gDNA chr17:g.7670630C>G
cDNA c.1079G>C
Protein p.G360A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126112 chr17:g.7670630C>G c.1079G>C p.G360A RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7670630C>G c.1079G>C p.G360A RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7670630C>G c.1079G>C p.G360A RefSeq GRCh38/hg38
NM_000546 chr17:g.7670630C>G c.1079G>C p.G360A RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7670630C>G c.1079G>C p.G360A RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7670630C>G c.1079G>C p.G360A RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7670630C>G c.1079G>C p.G360A RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7670630C>G c.1079G>C p.G360A RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7670630C>G c.1079G>C p.G360A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References