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Gene | TP53 |
Variant | S127F |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | TP53 S127F lies within the DNA-binding domain of the Tp53 protein (PMID: 21760703). S127F results in decreased Tp53 transactivation activity in yeast (PMID: 16000567), but has not been characterized in human cells and therefore, its effect on Tp53 protein function is unknown (PubMed, Feb 2025). |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon5 TP53 S127F |
Transcript | NM_000546.6 |
gDNA | chr17:g.7675232G>A |
cDNA | c.380C>T |
Protein | p.S127F |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |