FGFR1 C178S
Gene Variant Detail

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Gene FGFR1
Variant C178S
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions FGFR1 C178S lies within Ig-like C2-type domain 2 of the Fgfr1 protein (UniProt.org). C178S results in stabilization of the Fgfr1 dimer state in an in vitro assay (PMID: 27596331), and therefore, is predicted to lead to a gain of Fgfr1 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 act mut FGFR1 C178S

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Transcript NM_023110.3
gDNA chr8:g.38428010A>T
cDNA c.532T>A
Protein p.C178S
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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