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Gene FGFR2
Variant M540A
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions FGFR2 M540A lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). M540A demonstrates decreased kinase activity compared to wild-type Fgfr2 in an in vitro assay (PMID: 28166054), and therefore, is predicted to lead to a loss of Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 inact mut FGFR2 M540A

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Transcript NM_000141.5
gDNA chr10:g.121498548_121498549delATinsGC
cDNA c.1618_1619delATinsGC
Protein p.M540A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000141.4 chr10:g.121498548_121498549delATinsGC c.1618_1619delATinsGC p.M540A RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121498548_121498549delATinsGC c.1618_1619delATinsGC p.M540A RefSeq GRCh38/hg38
NM_000141 chr10:g.121498548_121498549delATinsGC c.1618_1619delATinsGC p.M540A RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries