We’re improving your experience!

×

Starting April 21, you’ll be asked to log in or sign up for a free account after viewing 10 content pages each month.

Don’t worry—creating an account is quick and easy, and it comes with added benefits! Once logged in, you’ll not only continue accessing the content you already enjoy, but you’ll also unlock exclusive features like interactive donut plots for variant protein effects and variant impacts across the gene.

Stay tuned for these updates, and thank you for being part of our community!

FGFR1 I544V - Gene Variant Detail

Request Content

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene FGFR1
Variant I544V
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions FGFR1 I544V lies within the protein kinase domain of the Fgfr1 protein (UniProt.org). I544V demonstrates increased kinase activity compared to wild-type Fgfr1 in an in vitro assay (PMID: 28166054), and therefore, is predicted to lead to a gain of Fgfr1 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 act mut FGFR1 I544V

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_023110.3
gDNA chr8:g.38417339T>C
cDNA c.1630A>G
Protein p.I544V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006716304.1 chr8:g.38417339T>C c.1630A>G p.I544V RefSeq GRCh38/hg38
XM_017013221.1 chr8:g.38417339T>C c.1630A>G p.I544V RefSeq GRCh38/hg38
XM_006716304.2 chr8:g.38417339T>C c.1630A>G p.I544V RefSeq GRCh38/hg38
NM_023110.2 chr8:g.38417339T>C c.1630A>G p.I544V RefSeq GRCh38/hg38
NM_023110.3 chr8:g.38417339T>C c.1630A>G p.I544V RefSeq GRCh38/hg38
XM_006716303.3 chr8:g.38417339T>C c.1630A>G p.I544V RefSeq GRCh38/hg38
XM_017013221.2 chr8:g.38417339T>C c.1630A>G p.I544V RefSeq GRCh38/hg38
XM_006716303.4 chr8:g.38417339T>C c.1630A>G p.I544V RefSeq GRCh38/hg38
XM_017013221 chr8:g.38417339T>C c.1630A>G p.I544V RefSeq GRCh38/hg38
NM_023110 chr8:g.38417339T>C c.1630A>G p.I544V RefSeq GRCh38/hg38
XM_006716304 chr8:g.38417339T>C c.1630A>G p.I544V RefSeq GRCh38/hg38
XM_006716303 chr8:g.38417339T>C c.1630A>G p.I544V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References