Gene Variant Detail

Gene	RAD51C
Variant	M1?
Impact List	unknown
Protein Effect	unknown
Gene Variant Descriptions	RAD51C M1? indicates a disruption of the methionine (M) start codon with an unknown translational effect on the Rad51c protein. M1? has not been characterized, however, a version of Rad51c utilizing an alternate methionine at codon 10 decreases mitomycin C sensitivity similar to full-length Rad51c (PMID: 12966089), and therefore, its effect on Rad51c function is unknown (PubMed, Oct 2024).
Associated Drug Resistance
Category Variants Paths	RAD51C mutant RAD51C M1?

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Transcript	gDNA	cDNA	Protein	Source Database	Genome Build
XM_017024915.1	chr17:g.58695137_58695139	c.1_3	p.M1	RefSeq	GRCh38/hg38
XM_006722004.4	chr17:g.58695137_58695139	c.1_3	p.M1	RefSeq	GRCh38/hg38
XM_006722001.4	chr17:g.58692644_58692646	c.1_3	p.M1	RefSeq	GRCh38/hg38
XM_011525094.2	chr17:g.58695137_58695139	c.1_3	p.M1	RefSeq	GRCh38/hg38
XM_017024916.1	chr17:g.58695137_58695139	c.1_3	p.M1	RefSeq	GRCh38/hg38
XM_047436505.1	chr17:g.58692644_58692646	c.1_3	p.M1	RefSeq	GRCh38/hg38
XM_006722001.5	chr17:g.58692644_58692646	c.1_3	p.M1	RefSeq	GRCh38/hg38
XM_017024917.1	chr17:g.58695137_58695139	c.1_3	p.M1	RefSeq	GRCh38/hg38
XM_011525092.2	chr17:g.58695137_58695139	c.1_3	p.M1	RefSeq	GRCh38/hg38
XM_006722004.3	chr17:g.58695137_58695139	c.1_3	p.M1	RefSeq	GRCh38/hg38
XM_017024914.1	chr17:g.58695137_58695139	c.1_3	p.M1	RefSeq	GRCh38/hg38
XM_006722002.5	chr17:g.58692644_58692646	c.1_3	p.M1	RefSeq	GRCh38/hg38
XM_006722005.3	chr17:g.58695137_58695139	c.1_3	p.M1	RefSeq	GRCh38/hg38
NM_058216.2	chr17:g.58692644_58692646	c.1_3	p.M1	RefSeq	GRCh38/hg38
XM_017024918.2	chr17:g.58695137_58695139	c.1_3	p.M1	RefSeq	GRCh38/hg38
XM_006722002.4	chr17:g.58692644_58692646	c.1_3	p.M1	RefSeq	GRCh38/hg38
XM_011525093.2	chr17:g.58695137_58695139	c.1_3	p.M1	RefSeq	GRCh38/hg38
NM_002876.3	chr17:g.58692644_58692646	c.1_3	p.M1	RefSeq	GRCh38/hg38
NM_058216.3	chr17:g.58692644_58692646	c.1_3	p.M1	RefSeq	GRCh38/hg38
XM_017024919.1	chr17:g.58695137_58695139	c.1_3	p.M1	RefSeq	GRCh38/hg38
XM_011525094.3	chr17:g.58695137_58695139	c.1_3	p.M1	RefSeq	GRCh38/hg38
NM_002876.4	chr17:g.58692644_58692646	c.1_3	p.M1	RefSeq	GRCh38/hg38

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References