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Gene FGFR2
Variant K660M
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 K660M (corresponds to K659M in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). K660M has been associated with resistance to Fgfr inhibitors in the context of an FGFR2 fusion (PMID: 31109923), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance Y
Category Variants Paths

FGFR2 mutant FGFR2 K660M

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Transcript NM_022970.4
gDNA chr10:g.121488001T>A
cDNA c.1979A>T
Protein p.K660M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_022970 chr10:g.121488001T>A c.1979A>T p.K660M RefSeq GRCh38/hg38
NM_001144913 chr10:g.121488001T>A c.1979A>T p.K660M RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121488001T>A c.1979A>T p.K660M RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121488001T>A c.1979A>T p.K660M RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121488001T>A c.1979A>T p.K660M RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121488001T>A c.1979A>T p.K660M RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References