FGFR2 K715R
Gene Variant Detail

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Gene FGFR2
Variant K715R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 K715R (corresponds to K714R in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). K715R has been identified in the scientific literature (PMID: 37843855, PMID: 31109923), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Dec 2025).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 K715R

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Transcript NM_001144913.1
gDNA chr10:g.121485449T>C
cDNA c.2144A>G
Protein p.K715R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001320658.1 chr10:g.121485440T>C c.2144A>G p.K715R RefSeq GRCh38/hg38
NM_001144913 chr10:g.121485449T>C c.2144A>G p.K715R RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121485449T>C c.2144A>G p.K715R RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121485449T>C c.2144A>G p.K715R RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121485449T>C c.2144A>G p.K715R RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121485440T>C c.2144A>G p.K715R RefSeq GRCh38/hg38
NM_022970 chr10:g.121485449T>C c.2144A>G p.K715R RefSeq GRCh38/hg38
NM_001320658 chr10:g.121485440T>C c.2144A>G p.K715R RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121485449T>C c.2144A>G p.K715R RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References