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Gene FGFR2
Variant K715R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 K715R (corresponds to K714R in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). K715R has been associated with resistance to Fgfr inhibitors in the context of an FGFR2 fusion (PMID: 31109923), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance Y
Category Variants Paths

FGFR2 mutant FGFR2 K715R

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Transcript NM_001144913.1
gDNA chr10:g.121485449T>C
cDNA c.2144A>G
Protein p.K715R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_022970 chr10:g.121485449T>C c.2144A>G p.K715R RefSeq GRCh38/hg38
NM_001320658 chr10:g.121485440T>C c.2144A>G p.K715R RefSeq GRCh38/hg38
NM_001144913 chr10:g.121485449T>C c.2144A>G p.K715R RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121485449T>C c.2144A>G p.K715R RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121485449T>C c.2144A>G p.K715R RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121485449T>C c.2144A>G p.K715R RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121485449T>C c.2144A>G p.K715R RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121485440T>C c.2144A>G p.K715R RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121485440T>C c.2144A>G p.K715R RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References