FGFR1 Y372C
Gene Variant Detail

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Gene FGFR1
Variant Y372C
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions FGFR1 Y372C (corresponds to Y374C in the canonical isoform) lies within the extracellular domain of the Fgfr1 protein (UniProt.org). Y372C results in increased basal and ligand-induced Fgfr1 activity in a luciferase assay (PMID: 15625620), and therefore, is predicted to lead to a gain of Fgfr1 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 act mut FGFR1 Y372C

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Transcript NM_015850.4
gDNA chr8:g.38419696T>C
cDNA c.1115A>G
Protein p.Y372C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_015850 chr8:g.38419696T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_011544446 chr8:g.38421862T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_047421569.1 chr8:g.38419696T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_047421573.1 chr8:g.38418270T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
NM_015850.4 chr8:g.38419696T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
NM_023106 chr8:g.38418270T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
NM_001174065.2 chr8:g.38419696T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
NM_023106.3 chr8:g.38418270T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_006716307.2 chr8:g.38419696T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_047421575.1 chr8:g.38421862T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_011544447 chr8:g.38421862T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
NM_001174064 chr8:g.38419678T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
NM_001354370.2 chr8:g.38418270T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_006716307 chr8:g.38419696T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_024447097.1 chr8:g.38419678T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_011544445.2 chr8:g.38421862T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
NM_001174064.1 chr8:g.38419678T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
NM_001174065.1 chr8:g.38419696T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
NM_001174064.2 chr8:g.38419678T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_024447097.1 chr8:g.38419678T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_017013224.2 chr8:g.38419696T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_011544447.2 chr8:g.38421862T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_011544446.3 chr8:g.38421862T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
NM_001354370.1 chr8:g.38418270T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_011544443 chr8:g.38421862T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_017013225.2 chr8:g.38419696T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_017013223 chr8:g.38419696T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
NM_001174065 chr8:g.38419696T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_006716309 chr8:g.38419678T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
NM_023106.2 chr8:g.38418270T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_006716314 chr8:g.38418270T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_011544445.3 chr8:g.38421862T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
NM_001354369.1 chr8:g.38419696T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
NM_001354367.2 chr8:g.38419696T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
NM_001354367.1 chr8:g.38419696T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
NM_001354369.2 chr8:g.38419696T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
NM_015850.3 chr8:g.38419696T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_006716307.1 chr8:g.38419696T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_011544443.2 chr8:g.38421862T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_006716314.2 chr8:g.38418270T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_017013225.3 chr8:g.38419696T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_006716306 chr8:g.38419696T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_011544447.3 chr8:g.38421862T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_006716313 chr8:g.38418270T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_011544445 chr8:g.38421862T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_006716314.3 chr8:g.38418270T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_017013225 chr8:g.38419696T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
NM_001410922.1 chr8:g.38419696T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_017013224 chr8:g.38419696T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38
XM_011544446.2 chr8:g.38421862T>C c.1115A>G p.Y372C RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries