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Gene PIK3CA
Variant I391M
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA I391M lies within the C2 PI3K-type domain of the Pik3ca protein (UniProt.org). I391M demonstrates kinase activity similar to wild-type Pik3ca in one study (PMID: 20530683), but results in increased cell proliferation and cell viability as compared to wild-type Pik3ca in one of two different cell lines (PMID: 29533785), and therefore, its effect on Pik3ca protein function is unknown.
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA I391M

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Transcript NM_006218.4
gDNA chr3:g.179209622A>G
cDNA c.1173A>G
Protein p.I391M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218 chr3:g.179209622A>G c.1173A>G p.I391M RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179209622A>G c.1173A>G p.I391M RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179209622A>G c.1173A>G p.I391M RefSeq GRCh38/hg38
XM_011512894 chr3:g.179209622A>G c.1173A>G p.I391M RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179209622A>G c.1173A>G p.I391M RefSeq GRCh38/hg38
XM_006713658 chr3:g.179209622A>G c.1173A>G p.I391M RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179209622A>G c.1173A>G p.I391M RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179209622A>G c.1173A>G p.I391M RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA I391M uterine cancer predicted - sensitive Sirolimus Case Reports/Case Series Actionable In a clinical case study, a uterine cancer patient harboring PIK3CA I391M demonstrated stable disease when treated with Rapamune (sirolimus) (PMID: 28514312). 28514312