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TP53 C275Wfs*70 - Gene Variant Detail

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Gene TP53
Variant C275Wfs*70
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 C275Wfs*70 indicates a shift in the reading frame starting at amino acid 275 and terminating 70 residues downstream causing a premature truncation of the 393 amino acid Tp53 protein (UniProt.org). C275Wfs*70 has not been biochemically characterized, but can be predicted to lead to a loss of Tp53 protein function due to the effects of C275* (PMID: 25584008).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon8 TP53 C275Wfs*70

TP53 mutant TP53 inact mut TP53 C275Wfs*70

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Transcript NM_000546.6
gDNA chr17:g.7673795delA
cDNA c.825delT
Protein p.C275Wfs*70
Source Database RefSeq
Genome Build GRCh38/hg38

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